|
rs1487151044
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, c.353T>C was correlated with lung cancer stages in smoking patients (P = 0.013), and those with the c.353C genotypes were less likely to have metastasis at diagnosis than those with the c.353TT genotype (OR, 0.60; 95% CI, 0.41-0.88).
|
24354880 |
2014 |
|
rs754854286
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Bioluminescent imaging showed that intracardiac injection of MCF7/TG2-C277S cells in mice promoted bone tumors, especially in the knee and jaw, but MCF7/TG2-C277S cells ectopically expressing miR-205 did not metastasize.
|
30949413 |
2019 |
|
rs762471803
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, we demonstrate that SYNPO2 inhibits the activities of YAP and TAZ by stabilizing LATS2 protein, and transduction of YAP-S127A abrogates the repressive role of SYNPO2 in metastasis.
|
28991374 |
2018 |
|
rs3213245
|
|
|
0.010 |
GeneticVariation |
BEFREE |
OS patients carrying TC genotype and C allele at rs3213245 were more likely to be with larger tumor size and metastasis.
|
30464596 |
2018 |
|
rs1799782
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results showed that Trp/Trp genotype of XRCC1 Arg194Trp and AA genotype of ERCC1 rs2336219 have a significantly increased risk of CRC; Trp allele of XRCC1 Arg194Trp and CC genotype of ERCC1 rs735482 were associated with lower response to oxaliplatin-based chemotherapy, a shorter survival and a higher risk of relapse or metastasis.
|
25690281 |
2015 |
|
rs1799782
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<i>XRCC1</i> rs1799782 may play an important role in the development and metastasis of breast cancer.
|
30568466 |
2018 |
|
rs1317052311
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Notably, LCN2 was significantly associated with distant tumor recurrences, as well as with the S100A family of metastasis related genes.
|
22559235 |
2012 |
|
rs1212415280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Notably, LCN2 was significantly associated with distant tumor recurrences, as well as with the S100A family of metastasis related genes.
|
22559235 |
2012 |
|
rs1284410244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To directly assess its role in tumor growth and metastasis in vivo, we stably transfected HT-1080 fibrosarcoma cells expressing either fully active wild-type human TFPI-2 (WT) or inactive R24Q TFPI-2 (QT) and examined their ability to form tumors and metastasize in athymic mice in comparison to mock-transfected cells (MT).
|
14525759 |
2004 |
|
rs1570360
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the multivariate model, significant associations and trends with shorter PFS were found for synchronous metastases (HR 1.94, p = 0.002), KIT exon 9 mutation (HR 2.45, p = 0.002) and the SNPs rs1870377 (AA genotype, HR 2.61, p = 0.015), rs1570360 (AA genotype, HR 2.02, p = 0.037) and rs4149117 (T allele, HR 0.62, p = 0.083).
|
29054076 |
2017 |
|
rs699947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results seem to indicate that combining information from genotyping of rs6</span>99947 (VEGFA, AC), rs2269772 (ITGA, AA) and tumour histology could allow clinicians to individuate gastric cancer at high risk for recurrence either with peritoneal or hematogenous metastases.
|
22808003 |
2012 |
|
rs1196644309
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thioredoxin-1 promotes colorectal cancer invasion and metastasis through crosstalk with S100P.
|
28483515 |
2017 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Latency was shortened by combining Kras(G12D) activation with heterozygous or homozygous deletion of p53 (mean survival of 56 weeks vs. 19 weeks, respectively), which also resulted in widespread local and distant metastasis.
|
22266220 |
2012 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In summary, by using 'knock-in' mutations of Trp53 we have identified two critical acquired functions of a stably expressed mutant form of p53 that drive PDAC; first, an escape from Kras(G12D)-induced senescence/growth arrest and second, the promotion of metastasis.
|
20018721 |
2010 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Orthotopic implantation of PDCs carrying the activated Kras(G12D)-allele and shRNA against p16(Ink4a) or Trp53 resulted in tumor growth, metastasis, and reduced survival of NSG mice.
|
25724428 |
2015 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Further, in order to investigate whether IL-6 deletion contributes to suppression of lung cancer metastasis, we generated Kras(G12D); p53(flox/flox); IL-6(-/-) mice, which developed lung cancer with a trend for reduced metastases and longer survival than Kras(G12D); p53(flox/flox) mice.
|
24260500 |
2013 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No associations were found among the SNP309, Arg72Pro, risk of CM, age at diagnosis and presence of metastasis in total subjects and when stratified according to the gender.
|
20535124 |
2010 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and heterozygous frequency of Arg/Pro72 genotype was 60% which could be associated as risk factor for metastasis (p = 0.046 OR = 4.190).
|
25027116 |
2014 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 codon 72 (rs1042522) genes may contribute to susceptibility to childhood ALL because they affect some important processes, such as metastasis regulation and tumor suppression.
|
23653000 |
2013 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and heterozygous frequency of Arg/Pro72 genotype was 60% which could be associated as risk factor for metastasis (p = 0.046 OR = 4.190).
|
25027116 |
2014 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No associations were found among the SNP309, Arg72Pro, risk of CM, age at diagnosis and presence of metastasis in total subjects and when stratified according to the gender.
|
20535124 |
2010 |
|
rs121912664
|
|
|
0.020 |
GeneticVariation |
BEFREE |
DNA from intra-surgical specimens revealed a TP53 mutation at codon 337 (p.R337H) in samples with neoplastic cells (dysplasia, tumor and metastasis) but not in non-transformed cells (incomplete intestinal metaplasia and non-involved celiac lymph node).
|
22004116 |
2011 |
|
rs121912664
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among the 19 patients with the Arg337His mutation, only one boy and three adults showed fatal evolution or recurrent metastases.
|
11600572 |
2001 |
|
rs28934576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Together, these results reveal an important role for DLX2-NRP2 in p53-R273H</span>-induced cell mobility and tumor metastasis.
|
28796261 |
2017 |
|
rs28934576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Taken together, these results suggest that transdominance of R273H mutant over wt p53 rather than a gain-of-function promotes tumor metastasis by increasing invasion and migration in HHUA cells.
|
17636407 |
2007 |